The Effect of Regular Exercise on Development of Sarcoma Tumor and Oxidative Damage in Mice Liver
Maria Sasvari1, Albert W. Taylor2, Dezso Gaal3, Zsolt Radak1,
Author Information
1 Institute of Sport Science, Faculty of Physical Education and Sport Sciences, Semmelweis University Budapest, Hun-gary
2 School of Kinesiology, Faculty of Health Sciences and Department Physiology, Faculty of Medicine and Den-tistry, University of Western Ontario, London, Canada
3 National Institute of Oncology, Budapest, Hungary
Zsolt Radak ✉ Institute of Sport Science, Faculty of Physical Education and Sport Sciences, Semmelweis Univ. TF, Alkotas u. 44, Budapest, Hungary Email: radak@mail.hupe.hu
Publish Date
Received: 31-03-2010 Accepted: 09-11-2010 Published (online): 01-03-2011
Maria Sasvari, Albert W. Taylor, Dezso Gaal, Zsolt Radak. (2011) The Effect of Regular Exercise on Development of Sarcoma Tumor and Oxidative Damage in Mice Liver. Journal of Sports Science and Medicine(10), 93 - 96.
Maria Sasvari, Albert W. Taylor, Dezso Gaal, Zsolt Radak. (2011) The Effect of Regular Exercise on Development of Sarcoma Tumor and Oxidative Damage in Mice Liver. Journal of Sports Science and Medicine(10), 93 - 96.
Regular exercise has the capability of decreasing the incidence and progress of certain cancers. Murine sarcoma, (S-180) cells were transplanted to control (TC), exercise trained (10 week, 1 hour day, 5 times/ week) mice, which had the swimming training terminated at the time of transplantation (ETT), and also to a group of mice that continued to exercise during tumor bearing (ETC). Continuous exercise decreased the size of tumor by about 50%. The accumulation of reactive carbonyl groups (RCD), were not significantly different for any group. The oxidative modification of proteins in the liver of the animals decreased in the exercise- trained non-tumor bearing group compared with control or tumor-bearing groups. No significant alteration was detected in the level of mutant p53. The data indicate that regular exercise retards the development of sarcoma solid tumors and it seems unlikely that massive uncompensated oxidative stress takes place in the tumor.
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